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The downregulation of OCTN2 activity and protein expression in the kidney reduces the reabsorption of carnitine in the kidney, leading to a decrease in carnitine availability in the liver and causing hepatic lipid metabolism disorders [260]

The funding sources had no influence on the study results, data interpretation, or decision to submit for publication

FMO3, both mRNA and protein, mutations of which cause trimethylaminuria, is first identified in 30% of foetal livers in the first trimester of pregnancy, disappears in the second and third trimesters, but identified again by 21 post-natal days irrespective of gestation

Yang TL, Shen H, Liu A, Dong SS, Zhang L, Deng FY, et al

(2019) demonstrated that serum levels of TMAO are positively correlated with the serum levels of total BA in patients with MAFLD by conducting a case-control study, and administration of TMAO impairs liver function and increases hepatic triglyceride accumulation and lipogenesis in a murine model